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The Genetics of Life and Death: Virus-Host Interactions Underpinning Resistance to African Swine Fever, a Viral Hemorrhagic Disease
Conclusion and Future Perspectives The mechanisms which result in reduced viral replication and lack of disease in African wild suids after ASFV infection are largely unknown. The data so far indicate that this is not due to an intrinsic difference in the ability of the virus to replicate in macrophages from these hosts. A more likely explanation is that the innate immune system of these hosts is better able to control virus replication resulting in a reduced systemic infection and reduced pathogenesis. This may involve a balance between virus and host factors which has evolved over long term infections of these hosts. Se...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

Sara—the Search and Rescue Dog—and her Game of Fetch
Editor’s note: Jana Sweeny is the American Red Cross’s Director of International Communications. She and her team are traveling around Colombia this week, visiting communities made safer by the Red Cross.   As we walk into the Colombian Red Cross training center in Pereira, a yellow lab comes bouncing up, waving her tail enthusiastically. The ball in her mouth turns out to be a lime and she is ready to play fetch. Because I can never say no to a dog, I begin a game of “fetch the lime” with her. It turns out that Sara isn’t just a fun companion–she is a retired search and rescue dog.  The Colo...
Source: Red Cross Chat - January 24, 2014 Category: Global & Universal Authors: Jenelle Eli Tags: International Preparedness colombia dogs pets Search and Rescue South America Source Type: news

Cardiovascular Parameters in a Swine Model of Normobaric Hypoxia Treated With 5-Hydroxymethyl-2-Furfural (5-HMF)
Conclusion: 5-HMF treatment decreased P50, improved SaO2, and mitigated increases in PAP in this swine model of NH. Introduction The reduction of barometric pressure at altitude is associated with reduced partial pressure of ambient Oxygen (PO2). With lower ambient PO2, it can be anticipated that alveolar (PAO2), arterial O2 (PaO2) and blood O2 content (CaO2) will decrease accordingly, resulting in a widely recognized decrease in maximal O2 consumption (VO2) (Dill and Adams, 1972; Lucas et al., 2011). In humans, with acute exposure to altitude, maximal VO2 decrements are measurable at elevations even as low as 580 ...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

A novel and effective balanced intravenous-inhalant anaesthetic protocol in Swine by using unrestricted drugs.
This study demonstrates that the proposed balanced intravenous-inhalant protocol permits to carry out a very effective, stable and safe anaesthesia in swine undergoing deep anaesthesia. PMID: 25030879 [PubMed - in process]
Source: Experimental Animals - December 2, 2014 Category: Research Tags: Exp Anim Source Type: research

Video-assisted thoracoscopic surgery in swine: an animal model for thoracoscopic lobectomy training
The objective of this study is to demonstrate the technique of lobectomy using videothoracoscopy in swine, highlighting the steps to be taken during its use in surgical experimentation. METHODS During the advanced course on video-assisted and thoracoscopic procedures carried out at IRCAD Latin America, Barretos, Brazil, 40 swine were used for the hands-on course on video-assisted upper left lobectomy. Monopulmonary ventilation was performed by blocking the left main bronchus. Surgical procedures were performed using three ports and the anterior dissection technique (fissureless approach). The pulmonary hilar structures we...
Source: Interactive CardioVascular and Thoracic Surgery - July 22, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tedde, M. L., Brito Filho, F., Belmonte, E. d. A., Pinto Filho, D. R., Pereira, S. T. F. L., Okumura, E. M., Melani, A. G. F., Gossot, D. Tags: Cardiac - pharmacology, Education, Transplantation - heart Thoracic Source Type: research

Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method
Conclusion: Overall, the pocket profile method combined with binding preferences from HLA binding data shows significant promise for developing T cell epitope prediction tools for pigs. When combined with existing vaccine design algorithms, PigMatrix will be useful for developing genome-derived vaccines for a range of pig pathogens for which no effective vaccines currently exist (e.g. porcine reproductive and respiratory syndrome, influenza and porcine epidemic diarrhea).
Source: BMC Bioinformatics - September 15, 2015 Category: Bioinformatics Authors: Andres GutiérrezWilliam MartinChris Bailey-KelloggFrances TerryLeonard MoiseAnne De Groot Source Type: research

Swine Depopulation Training for USDA Veterinary Services
Funding Opportunity ID: 290031 Opportunity Number: USDA-GRANTS-110916-001 Opportunity Title: Swine Depopulation Training for USDA Veterinary ServicesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: AgricultureCategory Explanation: CFDA Number(s): 10.025Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Land-Grant Universities, Non-Land-Grant Colleges of Agriculture, Colleges of Veterinary Medicine, or State entitiesAgency C...
Source: Grants.gov - November 10, 2016 Category: Research Tags: Agriculture Source Type: funding

Educating youth swine exhibitors on influenza A virus transmission at agricultural fairs
Summary Influenza A virus (IAV) is a major zoonotic pathogen that threatens global public health. Novel strains of influenza A viruses pose a significant risk to public health due to their pandemic potential, and transmission of influenza A viruses from animals to humans is an important mechanism in the generation and introduction of IAVs that threaten human health. The purpose of this descriptive correlational study was to develop real‐life training scenarios to better inform swine exhibitors of the risks they may encounter when influenza A viruses are present in swine. Educational activities were implemented in five Oh...
Source: Zoonoses and Public Health - November 18, 2017 Category: Infectious Diseases Authors: J. M. Nolting, J. Midla, M. S. Whittington, S. D. Scheer, A. S. Bowman Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine
Conclusions This PIA model in swine could be used for research and development; objective benchmarking of agents, devices, and techniques; and in the training of neurointerventionalists.
Source: Journal of NeuroInterventional Surgery - August 17, 2023 Category: Neurosurgery Authors: Arturo Larco, J. L., Madhani, S. I., Liu, Y., Abbasi, M., Lylyk, P. N., Benike, A., Shahid, A., Tekin, B., Quinton, R., Savastano, L. E. Tags: Basic science Source Type: research

Development of a Closed Chest Model of Chronic Myocardial Infarction in Swine: Magnetic Resonance Imaging and Pathological Evaluation.
In conclusion, intracoronary ethanol administration in swine consistently results in infarction. The sustained compromise in heart function and myocardial thinning over time indicate that the model may be useful for the preclinical evaluation of and training in therapeutic approaches to heart failure. PMID: 24282645 [PubMed - as supplied by publisher]
Source: ISRN Cardiology - November 28, 2013 Category: Cardiology Authors: Crisóstomo V, Maestre J, Maynar M, Sun F, Báez-Díaz C, Usón J, Sánchez-Margallo FM Tags: ISRN Cardiol Source Type: research

Swine Composting Training for USDA Veterinary Services Employees
Funding Opportunity ID: 290147 Opportunity Number: USDA-GRANTS-111616-001 Opportunity Title: Swine Composting Training for USDA Veterinary Services EmployeesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: AgricultureCategory Explanation: CFDA Number(s): 10.025Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Land-Grant Universities, Non-Land-Grant Colleges of Agriculture, Colleges of Veterinary Medicine, or State entities...
Source: Grants.gov - November 17, 2016 Category: Research Tags: Agriculture Source Type: funding

Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine
We sought to determine the role of endurance exercise in coronary heart disease development in a swine model of familial hypercholesterolemia (FH) that exhibits robust, complex atherosclerosis. Quantitative in  vivo imaging of CHD was determined using coronary intravascular ultrasound. Prior and concommitent treadmill training failed to attenuate CHD in FH swine. AbstractHuman studies demonstrate that physical activity reduces both morbidity and mortality of coronary heart disease (CHD) including decreased progression and/or regression of CHD with life ‐style modification which includes exercise. However, evidence suppo...
Source: Physiological Reports - February 26, 2019 Category: Physiology Authors: Darla L. Tharp, Isabelle Masseau, Jan Ivey, Maurice Harold Laughlin, Douglas K. Bowles Tags: Original Research Source Type: research

Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins
This article is protected by copyright. All rights reserved.
Source: Experimental Physiology - November 12, 2013 Category: Physiology Authors: Grant H. Simmons, Jaume Padilla, Nathan T. Jenkins, M. Harold Laughlin Source Type: research

Microsurgical training model with nonliving swine head. Alternative for neurosurgical education.
CONCLUSION: The swine model perfectly simulates standard microneurosurgical procedures, and is a useful tool for developing and refining surgical skills. PMID: 24919051 [PubMed - in process]
Source: Acta Cirurgica Brasileira - June 1, 2014 Category: Surgery Authors: Aurich LA, Silva Junior LF, Monteiro FM, Ottoni AN, Jung GS, Ramina R Tags: Acta Cir Bras Source Type: research